Purpose of the test
Strontium is a non-essential element. It has relatively few, unusual uses in industry, such as in the manufacture of pyrotechnics, extraction of sugar from sugar beet molasses and in the manufacture of glass used for television tubes. Clinically, it is relevant due to in vivo similarities with calcium. The effects on calcium metabolism relevant to bone turnover are exploited in the treatment of osteoporosis using strontium Ranelate (Protelos): Serum/plasma strontium is measured to ensure compliance and the possibility of accumulation in patients.
Non-radioactive Strontium, in preference to 45Ca, has also been used clinically to assess calcium absorption: serum [Sr] is measured in such studies before and 4h after an oral Sr dose.
Toxicity in humans is not well documented, though animal studies have shown impaired function and structural changes to the kidney, liver, blood, and cardio-respiratory system following prolonged exposure to strontium by inhalation. Acute toxicity (respiratory failure and death) has been reported after i.v. administration to animals.
Serum/plasma: < 0.34 µmol/L up to 200 µmol/L (patients on Protelos).
Urine: < 3.4 µmol/24h
Serum/plasma (500µL, no anticoagulant, Li-Hep)
Urine (aliquot- 20 mL in sterile universal or complete 24h collection in acid-washed container)
Storage and Transport
Stable at 4°C for at least a week. Send by overnight first class post.
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