Purpose of the test
Catecholamines are a group of biogenic amines derived from the amino acid tyrosine and bearing the catechol (3,4-dihydroxyphenyl)-moiety. The group comprises of adrenaline, noradrenaline and dopamine. Measurement of these catecholamines is useful in the diagnosis of neurochromaffin tumours (phaeochromocytoma, neuroblastoma and paragangliomas). Catecholamine secreting tumours account for <0.5% of all hypertensive patients and measuring these biogenic amines is useful for screening purposes.
Noradrenaline and adrenaline are catalysed by catechol-O-methyl transferase to form normetanephrine and metanephrine respectively. Many clinical studies have shown the analysis of urine metanephrines to be more sensitive in phaeochromcytoma diagnosis than urine catecholamines.
Urine Normetnephrine = < 4.4µmol/24hr
Urine Metanephrine = < 2.0 µmol/24hr
Urine Normetnephrine = < 1.95 µmol/24hr
Urine Metanephrine = < 1.52 µmol/24hr
Sample – plain 24hr urine collection (acidified urine is also acceptable.)
Storage and Transport
Send the completed 24 hour urine collection to the Central Specimen Reception laboratory ASAP.
5 working days.
Price available on application - please contact email@example.com. Discounts could be available for significant workloads.
Dr. Hagosa Abraha
T 020 3299 4130
Dr. Roy Sherwood
T 020 3299 3726
Mr. Colin Stone
T 020 3299 4128