Infliximab/Anti-TNF alpha drug and anti-drug antibody
Biochemistry Overview / Directory
Purpose of the test
Anti-TNF therapy is one of a new class of drugs (biologic agents) that target specific proteins in the immune system known to increase arthritis and other inflammatory diseases such as inflammatory bowel disease, vasculitis, juvenile dermatomyositis. By blocking these proteins these drugs reduce inflammation but without causing side effects by blocking other important processes. Monitoring levels is useful to assess correct dosage and guide infusion intervals. Measurement of anti-drug antibodies identifies patients which may experience infusion reactions and/or a reduced duration of efficacy, due to drug immunogenicity.
Test panel includes both drug and anti drug antibody measurment. Interpretation will be provided. Other anti-TNF alpha drug measurements available (Infliximab, etanercept).
Reference Range
We recommend trough levels. For request form, please contact Gillian.Richards@gsts.com or Zehra.Arkir@gsts.com.
Sample Requirements
300 uL Serum - Frozen in Plain Glass or Plastic container
Storage and Transport
Frozen on dry ice. It is not necessary to inform the laboratory in advance. Please send to:
GSTS Central Specimen Reception
5th Floor, North Wing
St Thomas' Hospital
Westminster Bridge Road
SE1 7EH
Turnaround Time
On application, please contact Gillian.Richards@gsts.com or Zehra.Arkir@gsts.com.
Price
Price available on application - please contact John.Roberts@gstt.nhs.uk. Discounts could be available for significant workloads.
