Anti dsDNA antibodies
Immunology and Allergy Overview / Directory
Purpose of the test
Autoantibodies to double stranded DNA (dsDNA) are one of many autoantibodies to nuclear related antigens. They are of particular significance in the diagnosis and management of systemic lupus erythematosus (SLE) where there is evidence that the presence and quantity of antibody is related to disease activity. Hence, the quantitative determination of autoantibodies to dsDNA may act as a surrogate maker of therapeutic efficacy. SLE-like syndromes may be seen in response to certain drugs (drug induced lupus). This investigation is useful in differentiating true SLE from its drug-induced counterpart, as antibody to dsDNA is not found in the drug-induced form. The antigen used in this ELISA assay is a human recombinant dsDNA.
Sample Requirements
2 ml freshly separated serum
Storage and Transport
Serum stored at 4°C should be sent by first class post
Turnaround Time
5 working days
Time Limit for Extra Tests
Five days
Factors affecting results or interpretation
All tests are compromised by prolonged transit times. For this reason, date of bleed and date of postage must be provided with each request.
Price
Price available on application - please contact adrianturner1@nhs.net. Discounts could be available for significant workloads.
Contacts
John Cazabon or Rosemary Ebling, Lead Biomedical Scientists
T 020 3299 1559
Dr Ted Davies Consultant Clinical Scientist
T 020 3299 9000 Ex 8752
