Anti ENA antibodies
Immunology and Allergy Overview / Directory
Purpose of the test
The identification of autoantibodies to the ENA family is now standard in the investigation of the “rheumatological” disorders.
Antibodies to SS-A (Ro) and SS-B (La) are mainly associated with Sjogren’s syndrome but may be found in SLE and less frequently in similar disorders. Anti-Sm and anti-RNP are associated with SLE and mixed connective tissue disease. Anti-Scl 70 is associated with scleroderma while anti-Jo-1 is seen in dermatomyositis.
The screening test uses a mixture of the common ENAs (SS-A [Ro], SS-B [La], Scl 70, Sm/RNP, Sm and Jo-1) in an ELISA format. If a positive reaction is detected a further ELISA is used to identify the individual antigenic targets.
Sample Requirements
2 ml freshly separated serum
Storage and Transport
Serum stored at 4°C should be sent by first class post
Turnaround Time
5 working days
Time Limit for Extra Tests
Five days
Factors affecting results or interpretation
All tests are compromised by prolonged transit times. For this reason, date of bleed and date of postage must be provided with each request.
Price
Price available on application - please contact adrianturner1@nhs.net. Discounts could be available for significant workloads.
Contacts
John Cazabon or Rosemary Ebling, Lead Biomedical Scientists
T 020 3299 1559
Dr Ted Davies, Consultant Clinical Scientist
Telephone: 020 3299 9000 Ex 8752
