Anti Glutamic Acid Decarboxylase (GAD) Antibodies
Immunology and Allergy Overview / Directory
Purpose of the test
The assay detects antibody to the 65kD isoform of GAD. This autoantibody is seen in both type 1 diabetes and stiff man (person) syndrome. GAD 65 is a pancreatic beta cell antigen. Stiff man syndrome is characterised by fluctuating muscle spasm affecting the limbs and trunk and a heightened sensitivity to external stimuli. Anti-GAD antibodies interfere with the synthesis of neurotransmitters in stiff man syndrome.
Sample Requirements
2 ml freshly separated serum
Storage and Transport
Serum stored at minus 20°C soon after separation should be sent by first class post or courier service
Turnaround Time
Assay currently performed monthly
Time Limit for Extra Tests
Five days
Factors affecting results or interpretation
All tests are compromised by prolonged transit times. For this reason, date of bleed and date of postage must be provided with each request.
Price
Price available on application - please contact adrianturner1@nhs.net. Discounts could be available for significant workloads.
Contacts
Dr Ted Davies, Consultant Clinical Scientist
T 020 3299 9000 Ex 8752
John Cazabon or Rosemary Ebling, Lead Biomedical Scientists
T 020 3299 1559
