Purpose of the test
Liquid chromatography-tandem mass spectrometric monitoring of whole blood concentrations of mycophenolic acid. Gold-standard assay for best management of dosage of CellCept and Myfortic used in immunosuppression.
Please download the referrer notes below for further information.
Varies widely with indication and patient characteristics but usually within the range 1 –3.5 mg/L.
For further advice: T 020 3299 3147
Pre-dose whole blood sample taken in EDTA (1 mL minimum; 12h post-dose for bd dosing).
Please separate and ship plasma for assay.
Please submit with a request form showing the last dose, last dose time and sample time/date.
Storage and Transport
Mycophenolate is most stable in plasma stored at normal ambient temperatures or 4°C.
Ship adequately contained plasma samples by 1st class mail or courier depending on urgency.
Send directly to:
Institute of Liver Studies,
King’s College Hospital,
London SE5 9RS
Same day Monday to Friday for samples received before 3 to 3.30 pm.
Time Limit for Extra Tests
No other immunosuppressants are currently measured in plasma
Factors affecting results or interpretation
Interpretation is affected by indication for mycophenolate, time from start of therapy, immunosuppressant comedication and patient’s clinical condition. Results vary during co-medication with inducers and inhibitors of UDP-glucuronosyltransferase and with liver and renal function (see Purpose of the Test).
T 020 3299 3147
Tredger et al. Liver Transplantation 2004; 10: 492-502