Liquid chromatography-tandem mass spectrometric monitoring of whole blood concentrations of mycophenolic acid. Gold-standard assay for best management of dosage of CellCept and Myfortic used in immunosuppression.

Please download the referrer notes below for further information.

Mpa_110105

Varies widely with indication and patient characteristics but usually within the range 1 –3.5 mg/L.

For further advice: T 020 3299 3147

Pre-dose whole blood sample taken in EDTA (1 mL minimum; 12h post-dose for bd dosing).

Please separate and ship plasma for assay.

Please submit with a request form showing the last dose, last dose time and sample time/date.

Mycophenolate is most stable in plasma stored at normal ambient temperatures or 4°C.

Ship adequately contained plasma samples by 1st class mail or courier depending on urgency.

Send directly to:

IDM Service,

Institute of Liver Studies,

King’s College Hospital,

Denmark Hill,

London SE5 9RS

Same day Monday to Friday for samples received before 3 to 3.30 pm.

No other immunosuppressants are currently measured in plasma

Interpretation is affected by indication for mycophenolate, time from start of therapy, immunosuppressant comedication and patient’s clinical condition. Results vary during co-medication with inducers and inhibitors of UDP-glucuronosyltransferase and with liver and renal function (see Purpose of the Test).

On application

IDM service:

E kch-tr.KCHIDMService@nhs.net

T 020 3299 3147

Tredger et al. Liver Transplantation 2004; 10: 492-502

Ciclosporin - LC/MS

Everolimus

HBV DNA (quantitative)

HCV genotyping

HCV RNA (qualitative)

HCV RNA (quantitative)

HDV antibody (IgM)

HDV antibody (Total)

HEV antibody (IgG)

HEV antibody (IgM)

Liver biopsy

Mycophenolate – LC/MS

Sirolimus - LC/MS

Tacrolimus – LC/MS