Amisulpride
Toxicology Overview / Directory
Purpose of the test
Amisulpride (aminosultopride) is an atypical antipsychotic drug that has been in clinical use since 1992. It is supplied as the free base in 50, 100, 200 and 400 mg tablets or capsules for oral administration, as well as a 50 mg/mL solution for parenteral injection. It is readily absorbed following oral administration and is largely excreted unchanged. Its plasma half-life is ca. 12 h. Adverse reactions include somnolence, hypotension, dystonia, akathisia and extrapyramidal effects. Oral maintenance doses for adults range from 50–400 mg/d,
Amisulpride assay is sometimes useful in assessing adherence and in the diagnosis of acute poisoning. A target plasma concentration range of 100–400 µg/L during effective therapy has been suggested.
Sample Requirements
4 mL of ETDA whole blood is preferred. Serum or plasma can be used if required, but please avoid gel-separator tubes.
Storage and Transport
Please refrigerate (if possible) if not sending immediately. Send by first class post to:
Toxicology Unit
Top Floor, Bessemer Wing
King’s College Hospital
Denmark Hill
London SE5 9RS
Please use the form below, COMPLETE ALL FIELDS, and send as a hard copy with the sample.
PDF Request Form
Download Amisulpride Request Form
Turnaround Time
Results are available within 5 working days of receipt in the laboratory.
Price
Price available on application - please contact adrianturner1@nhs.net. Discounts could be available for significant workloads.
Contacts
Clinical Advice & Interpretation
Dr Bob Flanagan
T 020 3299 5881
Fax 020 3299 5888
Laboratory
Simon Handley
T 020 3299 5883
F 020 3299 5888
References
RJ Flanagan. TDM of antipsychotics. CPD Bull Clin Biochem (2006); 7: 3-18.
